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KMID : 0545120020120050829
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Journal of Microbiology and Biotechnology
2002 Volume.12 No. 5 p.829 ~ p.833
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PC-766B´ and PC-766B, 16-Membered Macrolide Angiogenesis Inhibitors Produced by Nocardia sp. RK97-56
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KO, HACK-RYONG/KO, HACK-RYONG
KAKEYA, HIDEAKI/YOSHIDA, ARIKA/ONOSE, RIE/UEKI, MASASHI/MUROI, MAKOTO/TAKATSUKI, AKIRA/KAKEYA, HIDEAKI/YOSHIDA, ARIKA/ONOSE, RIE/UEKI, MASASHI/MUROI, MAKOTO/TAKATSUKI, AKIRA
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Abstract
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Angiogenesis is an essential event in a variety of physiological and pathological processes. Therefore, effective inhibition of event is a promising strategy for treating angiogenesis-related diseases, including cancer. The current study investigated two unique bafilomycin-type macrolide inhibitors of angiogenesis, PC-766B´ (1) and PC-766B (2). The strain RK97-56 which produced the inhibitors was identified as Nocardia sp. by chemotaxonomic analyses, and the purification of the inhibitors was guided by their anti-angiogenic actives. PC-766B´ (1) and PC-766B (2) exhibited potent inhibitory activities towards endothelial cell migration stimulated by the vascular endothelial growth factor(VEGF).
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